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Rajvir Singh joined the University of Bridgeport faculty in 2023. Before this, he held a senior research scientist position at the Memorial Sloan Kettering Cancer Center, a senior postdoctoral scientist at the Icahn School of Medicine at Mount Sinai Hospital, and an associate research scientist at Yale University. As an adjunct faculty, Rajvir has taught at three colleges (Hunter College, City Tech, and LaGuardia Community College) of City University of New York (CUNY), and St. John’s University, and Touro College of Osteopathic Medicine.
Singh’s broad range of research expertise includes the fields of metabolic syndrome (including insulin resistance, type 1 & 2 diabetes, obesity, dyslipidemia), atherosclerosis, Duchenne muscular dystrophy, diabetic cardiomyopathy, and lung diseases. He worked on several projects related to understanding the functional impact of human genetic variants, underlying diseases' mechanisms, and signaling pathways that regulate insulin signaling, glucose metabolism, adipogenesis, and inflammation. At Yale, Rajvir also worked on the effects of cigarette smoking and viral infection on lung inflammation and injury. His teaching includes biology and chemistry courses and provides hands-on research training for students majoring in biology and minoring in chemistry at the College of Science & Society.
Singh's current lab work focuses on two main areas: (1) studying the role of cigarette smoke extract (CSE) on lipids hydrolyzing enzymes, and (2) assessing how the lipid derivative such as ceramides modifies the functioning of immune cells. The lab also aims to investigate and enhance the use of T cell therapy for cancer and immune-related diseases.
PhD Biotechnology, Jawaharlal Nehru University, New Delhi, India
M.S. Biochemistry, Jamia Hamdard University, New Delhi, India
B.S. Biology, Chemistry Zoology, C.C.S. University, Meerut, UP, India
17. Singh R, Kaundal RK, Zhao B, Bouchareb R, Lebeche D (2021) Resistin induces cardiac fibroblast-myofibroblast differentiation through JAK/STAT3 and JNK/c-Jun signaling. Pharmacological Research, DOI: 10.1016/j.phrs.2020.105414
16. Dhandapany PS, Kang S, Kashyap DK, Rajagopal R, Sundaresan NR, Singh R, Thangaraj K, Jayaprakash S, Manjunath CN, Shenthar J, Lebeche D (2021) Adiponectin receptor 1 variants contribute to hypertrophic cardiomyopathy that can be reversed by rapamycin. Science Advances DOI:10.1126sciadv.abb3991
15. Singh R, Moreno PR, Hajjar RJ, Lebeche D (2018) A role for calcium in resistin transcriptional activation in diabetic hearts. Scientific Reports. 8, 15633 doi: 10.1038/s41598-018-34112-4
14. Mathiyalagan P, Adamiak M, Mayourian J, Sassi Y, Liang Y, Agarwal N, Jha D, Zhang S, Kohlbrenner E, Chepurko E, Chen J, Trivieri MG, Singh R, Bouchareb R, Fish K, Ishikawa K, Lebeche D, Hajjar RJ, Sahoo S (2018). FTO-Dependent m6A Regulates Cardiac Function During Remodeling and Repair. Circulation. 139(4):518-532
13. Hammoudi N, Jeong D, Singh R, Farhat A, Komajda M, Mayoux E, Hajjar R, Lebeche D (2017). Empagliflozin Improves Left Ventricular Diastolic Dysfunction in a Genetic Model of Type 2 Diabetes. Cardiovasc Drugs Ther.; 31(3):233-246.
12. Wang J, Liu W, Marion C, Singh R, Andrews N, Lee CG, Elias JE, Dela Cruz CS (2015)
Interleukin-15 Regulates Retinoic Acid Receptor Beta in the Lung During Cigarette Smoking and Influenza Virus Infection. Am J Respir Cell Mol Biol. DOI: 10.1165/rcmb.2014-0448OC
11. Keramati AR*, Fathzadeha M*, Go GW*, Singh R*, Choid M, Faramarzi S, Mane S, Kasaei M, Sarajzadeh-Fard K, Hwa J, Kidd KK, Babaee Bigi MA, Malekzadeh R, Hosseinian A, Babaie M , Lifton RP, and Mani A (2014) A Form of the Metabolic Syndrome Associated with Mutations in Dyrk1B.New England Journal of Medicine 370(20),1909-19
* First author, equal contribution.
10. Singh R, De Aguiar RB, Naik S, Mani S, Ostadsharif K, Wencker D, Sotoudeh M, Malekzadeh R, Sherwin RS, Mani R, (2013) LRP6 Enhances Glucose Metabolism by Promoting TCF7L2Dependent Insulin Receptor Expression and IGF Receptor Stabilization in Humans. Cell Metabolism 17, 197–209.
9. Singh R, Smith E, Fathzadeh M, Liu W, Go GW, Subrahmanyam L, Faramarzi S, McKenna W, Mani A, (2013) Rare Nonconservative LRP6 Mutations Are Associated with Metabolic Syndrome, Human Mutation 34:1221–1225
8. Liu W, Singh R, Choi CS, ….., Lifton RP, Shulman GI, Mani A, (2012) LRP6 regulates Body Weight and Glucose Homeostasis in Mice LDL Receptor Related Protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditure. J. Biol. Chem. 287(10):7213- 23.
7. Ye ZJ, Go GW, Singh R, Keramati AR, Mani A, (2012) LRP6 Protein Regulates Low Density Lipoprotein (LDL) Receptor-mediated LDL Uptake. J. Biol. Chem. 287(2):1335-44.
6. Keramati AR, Singh R, Lin A,…..Mane S, Tellides G, Liftton RP, Mani A, (2011) Wild-type LRP6 inhibits, whereas atherosclerosis-linked LRP6R611C increases PDFG-dependent vascular smooth muscle cell proliferation. Proc Natl Acad Sci U S A. 108(5):1914-8.
5. Patel T, Patel V, Singh R, Jayaraman S (2011) Chromatin remodeling resets the immune system to protect against autoimmune diabetes in mice. Immunology & Cell Biology, 89, 640–649
4. Jayaraman S, Patel T, Patel V, Ajani S, Garza R, Jayaraman A, Kwon S, Singh R, Rondelli D, Prabhakar BS, Holterman M. (2010) Transfusion of NOD mice with allogeneic newborn blood ameliorates autoimmune diabetes and modifies the expression of selected immune response genes. Journal of Immunology, 184(6):3008-15.
3. Graham KM, Singh R, Millman G, Malnassy G, Gatti F, Berge J, Bruemmer K, Stefanski C, Cortis H, Sesti J, Carlson CG. (2010) Excessive collagen accumulation in dystrophic (mdx) respiratory musculature is independent of enhanced activation of the NF-kB pathway. Journal of the Neurological Sciences 294 (1-2):43-50.
2. Carlson CG, Rutter J, Bledsoe C, Singh R, Hoff H, Bruemmer K, Sesti J Gatti F, Berge J, McCarthy L. (2010) A simple protocol for assessing inter-trial and inter-examiner reliability for two noninvasive measures of limb muscle strength. Journal of Neuroscience Methods186, (2), 226-230.
1. Singh R, Millman G, Turin E, Polisiakeiwicz L, Lee B, Gatti F, Berge J, Rutter J, Samadi A, Carlson CG. (2009) Increases in nuclear p65 activation in dystrophic skeletal muscle are secondary to increases in the cellular expression of p65 and are not solely produced by increases in IkappaB-alpha kinases activity. Journal of the Neurological Sciences 285, 159–171.